SLC29A1 and neoplasm: For instance, a retrospective analysis of a cohort of PDAC patients from the RTOG9704 phase III clinical trial, which compared gemcitabine with 5-FU after surgical resection, showed an association between high tumor hENT-1 expression and increased overall survival (OS) in patients who received gemcitabine (n = 91), but not in those who received 5-FU [43].