Validation of several identified mRNA species by real-time qPCR confirmed the downregulation of the proangiogenic Cyr61and Pgts2 as well as the proinflammatory Cox2 and Tnfrsf9 transcripts and the upregulation of a vessel-stabilizing factor Pdgfa in HIF-1α-KD tumor cells (Figure 3D). Here, TNFRSF9 is linked to neoplasm.