Transcriptome analysis of sorted MC-38 tumor cells revealed upregulation of vessel-stabilizing factors such as endostatin, Pdgfa, Thbs2 in HIF-1α-KD cells and reduced expression of pro-angiogenic factors such as Cyr61, Cox-2 and Angptl4 when compared to Mock tumors. The gene discussed is CCN1; the disease is neoplasm.