When we analyzed the polarization of macrophages into protumorigenic M2 or antitumorigenic M1 one using the CD206 and MHCII markers, respectively, increased numbers of M1 type macrophages in TRAF6-KD were observed (Figure 6E), which is in agreement with the observed tumor size reduction (Figure 6B). The gene discussed is TRAF6; the disease is neoplasm.