,21 In accordance with these findings, mutations in tumor protein p63 (transformation-related protein 63),22 a transcription factor upstream of Fgfr2 gene,23 cause ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome, with lacrimal duct agenesis overlapping with LADD.24 This evidence concerns the gene TP63 and LADD syndrome.