As before mentioned, five SAEs have been reported including a lupus-like syndrome, an AE rarely reported in literature with TNFα-inhibitors treatment [21], resolved after etanercept discontinuation, and a benign respiratory tract neoplasm, although Kimball and colleagues [22] demonstrated that neoplastic risk was higher in psoriatic patients but likely not related with biologic treatments. This evidence concerns the gene TNF and drug-induced lupus erythematosus.