We have reported only 11 not-severe cases of infections, in particular three candidiasis and four herpes simplex infections, two cases of pneumonia (of which one severe leading to hospitalization and drug discontinuation) and four rhino-pharyngitis, all in patients not in concomitant corticosteroids usage and only with TNF-α inhibitors (with the exception of one case of pharyngitis). This evidence concerns the gene TNF and herpes simplex infectious disease.