HMGB1 and Sepsis: In vitro a significant reduction for IL-6, IFN-y, MIP-1α, C5a, HMGB-1, procalcitonin and S100-A8, but not of TNF-α could be achieved in blood samples with sepsis-like high cytokine levels by binding to CytoSorb® hemoadsorbent polystyrene beads [15].