Although LGR5 mRNA expression was significantly increased in small bowel biopsies from SBS versus control patients and stem cell–initiated enteroid formation was greater in SBS patients compared with controls (Figure 1, Figure 2, and Figure 3), we observed patient-to-patient variability for all the analyses. Here, LGR5 is linked to macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.