Meanwhile, we assessed the relationship between DEPDC1 protein expression and clinicopathological parameters and concluded that high expression of DEPDC1 in CRC was correlated with TNM stage and recurrence (P < .001 and P = .003, respectively), while with no significant correlation between DEPDC1 expression and other clinicopathological features (such as age, gender, tumor size, tumor location, differentiation, or state of life, P > .05). Here, DEPDC1 is linked to neoplasm.