Harada Y et al discovered that DEPDC1 protein inhibits A20 gene expression through binding to ZNF224 (a transcription repressor), leading to IKB‐α protein phosphorylation and degradation, thereby promoting the separation and activation of NF‐κB and IKB‐α, causing its downstream DNA sites of tumor‐related target genes combined to activate oncogenes and induce bladder cancer.13 Here, DEPDC1 is linked to neoplasm.