FOXD2-AS1 is elevated in several cancers, such as nasopharyngeal carcinoma (NC) [13], hepatocellular carcinoma (HCC) [14–17], gastric cancer (GC) [18], colorectal cancer (CRC) [19,20], non-small cell lung cancer (NSCLC) [21,22] and esophageal squamous cell carcinoma (ESCC) [22–25], breast cancer [26], glioma [27–30] and so on. Here, FOXD2 is linked to esophageal squamous cell carcinoma.