Since the discovery of HMGB1 as a proinflammatory cytokine and late mediator of sepsis in 1999,12 extracellular HMGB1, which is mainly derived by active secretion from immune cells or passive release from damaged/dead cells, has attracted increasing attention as a damage‐associated molecular pattern (DAMP) that induces inflammation in immune cells. Here, HMGB1 is linked to Sepsis.