Additionally, HMGB1 also induced acute myeloid leukemia cells to release inflammatory factors and activated the receptor Tim‐3 to induce the secretion of vascular endothelial growth factor, which proves that HMGB1 contributes to the survival/proliferation of AML cells and that angiogenesis ultimately promotes the progression of AML.189. Here, VEGFA is linked to acute myeloid leukemia.