Paradoxically, the results of a cross‐sectional study conducted by Yates et al.76showed that there was no significant correlation between serum HMGB1 levels and histological characteristics such as steatosis, balloon‐like degeneration, inflammation, fibrosis, or steatohepatitis in children and adults with NAFLD and that serum HMGB1 levels did not change significantly during drug therapy. The gene discussed is HMGB1; the disease is steatosis.