The levels of HMGB1 in the CSF of children with bacterial meningitis or aseptic meningitis were all increased, but the concentrations of HMGB1 in the CSF of individuals with bacterial meningitis was four times that of individuals with aseptic meningitis, and there was a significant correlation between CSF HMGB1, WBC counts, and glucose in bacterial meningitis cases.126, 127. Here, HMGB1 is linked to bacterial meningitis.