In contrast, Zhuo et al.45reported that HMGB1 in peripheral monocytes in neonatal sepsis increased and activated the TLR4/NF‐κB pathway to produce inflammatory factors, while simvastatin combined with human‐derived kallikrein binding protein was used to treat children with burns complicated with sepsis and reduced the abnormally elevated HMGB1 in endothelial cells.46 The gene discussed is TLR4; the disease is Sepsis.