HMGB1 and Hypoglycemia: In fact, HMGB1 knockout causes lethal hypoglycemia in newborn mice within 24 h of birth; furthermore, although HMGB1‐deficient cell lines appear normal, glucocorticoid receptor‐activated gene expression is impaired, which suggests that HMGB1 is not necessary for overall chromatin structure but is essential for proper transcriptional regulation of specific transcription factors.5