As an important inflammatory mediator, the role of HMGB1 in asthma has also received attention; that is, the sputum HMGB1 levels of asthmatic children were significantly elevated compared with those of the healthy control group89, 90 and were positively correlated with the total IgE level,90 and the sputum HMGB1 levels of children with mild, moderate, or severe symptoms were strictly negatively correlated with the lung function index.90 This evidence concerns the gene HMGB1 and asthma.