In our study, EGFR mutations (52.2%) were the most frequent genetic alterations because of the prevalence of lung adenocarcinoma in Asia.17–19 Notably, the frequency of TP53 mutations (18.3%) was lower than that reported in previous studies (30–60%).19,20 The frequency of TP53 mutations increased as the stage increased.8 The reason for the low frequency of TP53 can be explained by our cohort of early-stage lung adenocarcinoma. This evidence concerns the gene TP53 and lung adenocarcinoma.