CTNNB1 and neoplasm: If it is not degraded by the aberration of Wnt/β-catenin signaling, it remains in the cytoplasm.25 The increased β-catenin in the cytoplasm moves to the nucleus, acts as a transcription factor to activate cell cycles continuously, and induces tumor formation.15,16,26,27 In our study, relapses of resected tumors with CTNNB1 mutations usually occur in distant organs.