N-803 significantly enhanced IFNγ production at an E:T ratio of 1:1 and 3:1 (Fig. 1h), upregulated ICAM-1 expression in the presence of HPC-NK cells (Fig. 1i) and most importantly increased primary AML killing by HPC-NK cells (Fig. 1j). This evidence concerns the gene ICAM1 and acute myeloid leukemia.