On the other hand, the ICR-Disabled list was associated with GO terms including “Negative Regulation of Cell Death”, “TGFB Signalling Pathway” and “Epithelial-to-Mesenchymal Transition” (EMT), which are involved in tumour progression with metastatic expansion, and the generation of tumour cells with stem cell properties that play a major role in resistance to cancer treatment.46,47 In the self-organising network plot of these GO terms, IE and ID signatures reflect two opposing networks, clustering separately (Fig. 3). Here, TGFB1 is linked to cancer.