TGFB1 and cancer: In addition, ICR moderately but consistently correlates with immuno-suppressive signatures such as TGFβ Response,15 Cancer-Associated Fibroblasts (CAF),34,35 ESTIMATE-Stroma,21 Epithelial–Mesenchymal Transition (EMT),36,37 PI3Kγ38–40 and LAP-Helios (with a mean correlation coefficient of 0.31).41 Intriguingly, MIRACLE (Fig. 2b) score is either not correlated or anti-correlated with these inhibitory signatures (mean correlation coefficient: −0.1, Table S5), while it is highly correlated with all the hallmarks of Th1-polarised T cell infiltration (Fig. 2b, Table S5).