The top genes of which mutations positively correlate with MIRACLE include genes that are associated with differential survival in cancer subtypes, such as IDH1, CIC and FUBP1 in glioma,44 whereas other genes associated with immune-evasion mechanisms that follow immunologic pressure such as mutations of antigen-presenting machinery transcripts previously described (i.e., B2M, VHL and CASP8).52 The gene discussed is CASP8; the disease is cancer.