SREBF1 and breast carcinoma: Similarly, mTORC1 plays a role in lipogenesis and induces lipid accumulation in cancer cells, which is also important in the development of treatment resistance.5 AMPK activation inhibits ACC, a precursor molecule for lipogenesis and SREBP1 that can inhibit lipid metabolism.5,31 Our results also suggest that SU212 treatment inhibits the accumulation of lipids in breast cancer cells via AMPK activation and ACC inhibition.