Kee, et al.28 reported that stress signals, such as hypertrophic stimuli and reactive oxygen species (ROS) to cardiomyocytes induce the expression of HSP70, followed by activation of cardiac histone deacetylase-2 (HDAC2) that triggers cardiac hypertrophy due to inhibition of antihypertrophic gene expression. The gene discussed is HSPA1A; the disease is cardiac hypertrophy.