CLDN12 and bipolar disorder: Additionally, levels of TJP1 (r = −0.561, *P < 0.05) and CLDN12 (r = −0.56, *P < 0.05) were negatively correlated with the duration of bipolar disorder in the occipital cortex and premotor frontal cortex respectively while CLDN12 (r = −0.547, *P < 0.05) was negatively correlated with the duration of schizophrenia in the cerebellum (Supplementary Fig. 3B).