CFAP45 and Situs inversus totalis: Similar to CFAP45-deficient individuals, these individuals presented mild chronic upper respiratory symptoms and situs inversus totalis (Supplementary Fig. 5c) but did not fulfill criteria for a PCD diagnosis (Supplementary Table 2); for example, male individual OI-81 II1 showed no evidence of bronchiectasis (Supplementary Fig. 5q) but reported infertility.