Consistent with Cfap45 expression in the mouse left–right organizer (LRO) and specific CFAP45 localization to motile cilia of the LRO (Fig. 4a-f), Cfap45−/− offspring presented LRA abnormalities including situs inversus totalis (Fig. 4; see also “Methods”). The gene discussed is CFAP45; the disease is Situs inversus totalis.