APOE and Alzheimer disease: The increases of Aβ40 (Fig. 3a), Aβ42 (Fig. 3b), and Aβ42/Aβ40 ratio (Fig. 3c) in AD organoid groups were magnified at week 12 independent of APOE4. Aβ40 and Aβ42 in detergent-insoluble FA fraction were undetectable at any time points.