RNF115 and viral infectious disease: To examine the role of RNF115 in host defense against viral infection in vivo, we infected the Rnf115+/+ and Rnf115−/− mice by intraperitoneal (i.p.)injection of SeV or intravenous (i.v.)injection of EMCV or HSV-1 followed by various analyses (Fig. 4a).