To further confirm disease-specificity, we screened an additional 42 CBD/PSP cases and found only four cases with rare ac-K311 immunoreactivity that was in the form of AD-like neuritic plaques and neuronal tangles that were both RD3 and RD4 positive, suggesting ac-K311 immunoreactivity predominantly occurs in 3R-tauopathies (Supplementary Table 1). This evidence concerns the gene ASAH1 and red-green color blindness.