While 3R-tau predominant Pick’s disease (PiD) was also strongly immunoreactive (Fig. 3c, see ac-K311 positive Pick bodies), surprisingly, 4R-tau predominant corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) showed minimal ac-K311 immunoreactivity (Fig. 3c, see ac-K311 negative CBD and PSP cases), despite the presence of phosphorylated tau inclusions in all tauopathy cases analyzed (Supplementary Fig. 5b). Here, MAPT is linked to Pick disease.