HDAC6 and amyotrophic lateral sclerosis: Indeed, loss or inhibition of HDAC6 was reported to stabilize MTs and improve axonal transport in nontauopathy syndromes including Charcot Marie Tooth (CMT) neuropathy51,52, amyotrophic lateral sclerosis (ALS)53, Rett syndrome54, and Aβ plaque deposition19.