While 3R-tau predominant Pick’s disease (PiD) was also strongly immunoreactive (Fig. 3c, see ac-K311 positive Pick bodies), surprisingly, 4R-tau predominant corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) showed minimal ac-K311 immunoreactivity (Fig. 3c, see ac-K311 negative CBD and PSP cases), despite the presence of phosphorylated tau inclusions in all tauopathy cases analyzed (Supplementary Fig. 5b). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.