In this scenario, 3R-tauopathies would be marked by distinct acetylation profiles compared to 4R-tauopathies, providing a unique tau PTM signature that could explain the specific conformation and/or aggregation of distinct tau isoforms in clinically diverse neurodegenerative tauopathies (see Supplementary Fig. 10 model). The gene discussed is MAPT; the disease is tauopathy.