Additionally, a panel of frontotemporal dementia (FTD) linked tau mutations (Supplementary Fig. 1a), many of which cluster in the R2 and R3 regions, showed a range of binding with some mutants showing increased HDAC6 binding (e.g., P301L and S320F) while others showed reduced HDAC6 binding (e.g., ΔK280 and L315R) (Fig. 1h, i). The gene discussed is MAPT; the disease is frontotemporal dementia.