The lack of ac-K311 pathology in CBD and PSP brain was unexpected since residue K311 is present in all six tau isoforms (both 3R-tau and 4R-tau) that form inclusions in AD (mixed 3R/4R tau pathology), PiD (3R tau pathology), and CBD/PSP (4R tau pathology). The gene discussed is MTA2; the disease is Alzheimer disease.