Further analysis with a panel of phosphorylated tau antibodies showed that CBP-mediated tau acetylation also led to increased tau phosphorylation at S262 and S356 (MARK2-dependent target KXGS motifs) as well as S202 and S404, but not other AD-relevant epitopes in the proline-rich (AT8 and T205) or C-terminal (S396) regions (Fig. 4a–d). The gene discussed is MARK2; the disease is Alzheimer disease.