HDAC6 and frontotemporal dementia: Additionally, a panel of frontotemporal dementia (FTD) linked tau mutations (Supplementary Fig. 1a), many of which cluster in the R2 and R3 regions, showed a range of binding with some mutants showing increased HDAC6 binding (e.g., P301L and S320F) while others showed reduced HDAC6 binding (e.g., ΔK280 and L315R) (Fig. 1h, i).