A study in mice found that β-cell dysfunction induced by forkhead box protein O1 (FoxO1) ablation resulted in hyperglycemia, loss of β-cell mass, β-cell demise, decreased plasma insulin levels, and decreased pancreatic insulin levels [59] suggestive of the progressive decline of β-cell function inherently associated with the development of both type 1 and 2 diabetes mellitus. Here, INS is linked to Hyperglycemia.