A recent longitudinal cohort study examined associations of circulating SHBG, estrogens and androgens with key histologic features of pediatric, biopsy-confirmed NAFLD and the results showed that lower SHBG levels were inversely associated with steatosis severity in boys and girls, and with portal inflammation in girls only [79], indicating that adipocyte-hepatocyte inflammatory crosstalk may exist in women with NAFLD. This evidence concerns the gene SHBG and metabolic dysfunction-associated steatotic liver disease.