A study using liver samples from nondiabetic obese patients with NAFLD demonstrated that triglycerides accumulate in the liver and insulin resistance (assessed by homeostatis model assessment, HOMA-IR) was inversely related to SHBG mRNA and to HNF4 α mRNA as well as to circulating SHBG levels [54]. The gene discussed is SHBG; the disease is metabolic dysfunction-associated steatotic liver disease.