Hepatic insulin resistance exacerbates hepatocellular effects on de novo lipogenesis (DNL) through transcriptional upregulation of several genes of DNL, including sterol regulatory element binding protein 1c (SREBP-1c), which promotes DNL by enhancing the transcription of several lipogenic enzymes, notably adenosine triphosphate citrate lyase (ACL), acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD1) [52]. This evidence concerns the gene ACACA and Insulin resistance.