Very recently, our group constructed a multifunctional nanotheranostic (MnIOMCP) for active tumor-targeting T1-/T2-weighted dual-mode MRI-guided biological-photothermal therapy (bio-PTT) through bioconjugation of the monocyclic peptides (MCP, the CXC chemokine receptor 4 (CXCR4) antagonist) with 3.8 nm manganese-doped iron oxide NDs (MnIO NDs) [146]. This evidence concerns the gene CXCR4 and neoplasm.