PTH and hyperphosphatemia: It should be emphasized, however, that the possibility of an indirect hormonal effect of hyperphosphatemia on endothelium (for example, a Pi-induced change in the circulating concentration of phosphatonins, such as parathyroid hormone or FGF23, which may then act on the endothelial cells) has not been ruled out, and studies of such factors would be an interesting subject for future research in this field.