From these patients, we purified total IgG fractions and tested them alongside IgG pooled from two patients with active catastrophic antiphospholipid syndrome as well as a separate IgG pool from five patients with antiphospholipid syndrome who tested positive for aCL antibodies, aβ2GPI antibodies, and lupus anticoagulant. The gene discussed is ACLY; the disease is antiphospholipid syndrome.