Antiphospholipid autoantibodies (aPL antibodies) are a heterogeneous group of antibodies that underlie the pathogenesis of antiphospholipid syndrome via their interactions with phospholipid-binding plasma proteins such as β2GPI, prothrombin, thrombomodulin, plasminogen, antithrombin III, protein C, protein S, annexin II, annexin V, and likely others (22, 41–46). Here, ANXA2 is linked to antiphospholipid syndrome.