PDCD10 and cerebral cavernous malformation: As several of these processes are indeed de-regulated in CCM malformations (Clatterbuck, 2001; Labauge et al., 2007; Abdelilah-Seyfried et al., 2020; Maddaluno et al., 2013; Bravi et al., 2016; Bravi et al., 2015), we speculate that the overexpression of at least some of these genes, alone or in concert, might contribute to maintenance of the normal phenotype of Pdcd10-deleted arterial ECs.