We show that plasma CXCL2, CXCL10, CCL5, CD40 ligand, IL-10, and GM-CSF concentrations and ELF CXCL1, CXCL10, granzyme B, TRAIL, and EGF concentrations were found in greater concentrations in COVID-19 than in non-COVID-19 ARDS patients. Here, GZMB is linked to acute respiratory distress syndrome.