Among 374 patients in our study with early-onset breast cancer (age < 35), the detection rate of a TP53 germline mutation was 3.74% which is comparable to other studies in the West (2–7.1%) [24, 25], and among Chinese high risk breast patients (1–5%) [12, 26, 27] (Table 2). The gene discussed is TP53; the disease is breast carcinoma.