Aggressive breast cancer is mainly regulated by the MNK/XIAP/NF-κB axis, MNK (MAPK iNteracting Kinase) activation increases the XIAP protein, facilitating the interaction between BIR1 domain and TAB1 (TGFβ-associated binding protein) together with its cognate kinase TAK1. This evidence concerns the gene ATP7A and breast carcinoma.