Here, we utilize two different models of inherited retinal degeneration, the rhodopsin P23H knockin (RhoP23H/+) model of RP [12,25] and the Prph2 Y141C knockin (Prph2Y141C/+) model of cone-rod dystrophy [13] to evaluate whether eliminating retbindin has broad effects on retinal degeneration. Here, PRPH2 is linked to Rod-cone dystrophy.