Here, we utilize two different models of inherited retinal degeneration, the rhodopsin P23H knockin (RhoP23H/+) model of RP [12,25] and the Prph2 Y141C knockin (Prph2Y141C/+) model of cone-rod dystrophy [13] to evaluate whether eliminating retbindin has broad effects on retinal degeneration. This evidence concerns the gene RHO and cone-rod dystrophy.