Top enriched markers in severe-COVID-19 BAL were spermidine/spermine N1-acetyltransferase 1 (SAT1), involved in the catabolic pathway of polyamine metabolism, LY8E, Spi-1 proto-oncogene (SPI1), Fc fragment of IgE, high-affinity I, receptor for gamma polypeptide involved in allergic reactions (FCER1G), and transforming growth factor beta 1 (TGFB1). The gene discussed is SPI1; the disease is COVID-19.