Additional studies demonstrate that PDE5 inhibition was able to attenuate the prolonged HPV in high-altitude hypoxia for 14 days [111] and prevent HAPE [112]; thus, in addition to NO, therapeutic PDE5 inhibition may also provide a benefit to patients with severe SARS-Cov2-induced ARDS. The gene discussed is PDE5A; the disease is acute respiratory distress syndrome.