This was corrected with treatment with either AM6545 (group M + A65) or AM4113 (M + A41), which caused a significant reduction in the insulin levels when compared to the metabolic syndrome group M. Treatment of control rats with AM6545 (group C + A65) and AM4113 (C + A41) showed no significant changes (p < 0.05) in serum insulin levels relative to group C (Figure 1c). The gene discussed is INS; the disease is metabolic syndrome.