Nobiletin repressed the development of human gastric TMK-1 cell lines, (IC50: 134.8 μM) through induction of apoptosis and cell cycle arrest in the G0/G1 phase [39], and suppress the expression of the crucial factor for endoplasmic reticulum stress such as thioredoxin-interacting protein (TXNIP), and consequently leads to cell apoptosis in human neuroblastoma cells [40]. This evidence concerns the gene TXNIP and neuroblastoma.