In stomach cancer (STAD), constitutive signaling by aberrant PI3K in cancer, PTEN loss of function in cancer (Figure S2a), deadenylation-dependent mRNA decay (Figure S2b), and transcriptional regulation of pluripotent stem cells (Figure S2c) are pathways that are well known to play important roles in the tumorigenesis and development of STAD [71,72]. The gene discussed is PIK3CA; the disease is gastric cancer.