We found some prognosis-related pathways of breast cancer, such as the regulation of insulin-like growth factor (IGF) transport and uptake by insulin-like growth factor binding proteins (IGFBPs), the PI3K/Akt signal transduction pathway, signaling by PDGF, Toll-like receptor cascades, DAP12 interactions, and constitutive signaling by aberrant PI3K in cancer. This evidence concerns the gene PIK3CA and breast cancer.