Prednisone (1.5mg/kg/day) did not prevent TBM-IRIS in a non-controlled cohort of 34 TBM patients, and dose-increase or restarting of prednisone at IRIS diagnosis decreased the concentration of only two inflammatory mediators (G-CSF, IL-37), while other markers of inflammation remained elevated from ART initiation [87]. Here, CSF3 is linked to meningeal tuberculosis.