Systemically, TB-IRIS is associated with upregulated transcripts of neutrophil activation genes (S100 calcium binding protein A9 (S100 A9), the NLR family pyrin domain containing 12 (NLRP12), cyclooxygenase 1 (COX-1) and IL-10) and increased blood levels of neutrophils, elastase, and human neutrophil peptides [85]. This evidence concerns the gene PTGS1 and tuberculosis.