There have been mixed findings on CD8 T cells, with evidence of decreased cell-signaling in IRIS patients [66], decreased activation pre-ART but not at IRIS onset [91], increased expression of cell-surface receptors killer cell ligand like receptor g1 (KLRG1) and programmed cell death protein 1 (PD-1) [92]; a study also found elevated CD8 T cells as a risk factor for TB-IRIS, with expansion of two subpopulations at IRIS onset [93]. This evidence concerns the gene CD8A and tuberculosis.