When these mice were injected with CIITA-driven MHC-II-expressing tumor cells, here we used the MC38 colon carcinoma and the LLC Lewis Lung carcinoma, after conditional depletion of DCs, they were still capable of rejecting tumor cells or strongly retard their growth, clearly showing that CIITA-driven MHC-II-expressing tumor cells were the most important surrogate APC in vivo for their own tumor antigens [56]. This evidence concerns the gene CIITA and Carcinoma, Lewis Lung.