Despite the fact that HbA1c, insulin use and/or diabetes duration were not significantly correlated with log calprotectin, and that addition of these variables to the multivariate logistic regression model for CVD did not materially change the standardized Beta (95% CI) for the association of the Z-score of log calprotectin with CVD, the accumulated evidence from prior studies makes it likely that glycosylation is an important contributor to the occurrence of CVD [25]. This evidence concerns the gene INS and diabetes mellitus.