The expression of DRAM1/Dram1 in primary human macrophages and the zebrafish model in response to mycobacterial infection relied on the MyD88 adaptor protein and NFκB transcription factor, both components of Toll-like receptor and IL-1β signaling, identifying this pathway as an infection-inducible mechanism downstream of PRRs [43]. This evidence concerns the gene DRAM1 and infection.