The results obtained show in both treated melanoma cell lines, the increase, time, and concentration dependent, of p53 expression (Figure 5A,D, upper panels; B and E) as well as the decrease, time, and concentration dependent of AKT signalling protein expression (Figure 5A,D, middle panels; C and F) compared to untreated cells (NT). The gene discussed is AKT1; the disease is melanoma.