Notably, an AFB1-induced toxic proinflammatory response, mediated by the increase of IL1A and IL6, has been previously noticed in macrophages collected from rats orally consecutively exposed to AFB1 for 2 weeks (corresponding to 0.03–0.7 mg/kg body weight) [103], in murine CNS-derived cells treated with their relative AFB1 LC50 dose [104], as well as in a rat model of HCC intraperitoneally injected with 1 mg/kg AFB1 [105]. Here, IL6 is linked to hepatocellular carcinoma.