In univariable Cox proportional hazard analysis, age, gender (male), ischemic heart disease, atrial fibrillation, MBP, hemoglobin, eGFR, sodium, blood urea nitrogen, log CRP, log BNP, history of HF, diuretics, log GNRI and log TCBI were associated with the all-cause mortality (Table 2a). The gene discussed is NPPB; the disease is atrial fibrillation.