The absence of CDKN2a, PTEN and TP53 in exosomal gDNA is prominent and interesting because of the presence of other GBM-relevant gDNA sequences such as EGFR, CDK4, AKT3, ERBB2m and MDM2 in GBM exosomes [3]. The gene discussed is EGFR; the disease is glioblastoma.