EZH2 and type 2 diabetes mellitus: We also found that EZH2 likely regulates the GLT-HDAC3-apoptosis axis in its capacity as a protein-methyltransferase or methylation-dependent transcriptional activator, but more studies are required to elucidate the primary mode of EZH2 function in metabolically stressed β-cells in vitro and in vivo to assess the translational relevance of targeting EZH2 in T2D.