While homozygous, β-cell specific EZH2 deficiency in RIP-Cre;Ezh2f/f or Pdx1-Cre;Ezh2f/f mice induces mild glucose-intolerance and reduced β-cell mass [30,33]; heterozygous Pdx1-Cre;Ezh2f/+ mice display increased β-cell mass [30]. This evidence concerns the gene PDX1 and Glucose intolerance.