H2S-releasing aspirin, MZe786, successfully reduced blood pressure, kidney damage and improved fetal outcome in Hmox1+/− mice under high levels of sFlt-1 in part, by increasing the release of H2S as its' metabolite, TMS, is increased in MZe786 treated group and not in the aspirin group. The gene discussed is HMOX1; the disease is Nephropathy.