Genes identified by our method suggest putative roles of several biological processes in Alzheimer’s disease, including mitochondrial dysfunction (indicated by UQCR11, MTCH2 and TMEM135), cholesterol transportation (indicated by TMEM135 and OSBP), and neuron activity (indicated by ADRA1A). The gene discussed is TMEM135; the disease is early-onset autosomal dominant Alzheimer disease.