COQ4 and Alzheimer disease: 1 identified by our method is a long non-coding RNA (lncRNA) located near the promoter region of CD2AP. The level of RP11-385F7.1 lncRNA has a strong Pearson correlation with gene expression level of COQ4 located on 16q22.3 [46], which was also the gene only identified by our method and encodes a protein that may serve as an antioxidant strategy target for AD [47].