To investigate whether Pi availability impacts skeletal muscle properties in CKD, we fed sham-operated and 5/6 nephrectomized (CKD) mice a high (2.0%) Pi (HP) diet for 5 months and then assessed blood chemistry, muscle weight, hindlimb grip strength, and Nrf2, p62, and myogenin expression in the gastrocnemius (GA) muscle. The gene discussed is NFE2L2; the disease is chronic kidney disease.