RNA methyltransferases (such as METTL14, METTL3 and TAP), the demethylases(such as ALKBH5 and FTO), and the binding proteins (such as YTHDF2 and YTHDF1) are often upregulated in a variety of human cancer types to increase the expression of oncogenes and oncoproteins [41]. The gene discussed is ALKBH5; the disease is cancer.