In our research, the most expression of m6A regulators including METTL14, METTL3, WTAP, KIAA1429, ZC3H13, RBM15, YTHDF2, YTHDC1, YTHDC2 and YTHDF1 were highly expressed in high-risk of melanoma patients, and hence we have enough reasons to believe that our UPRRGs feature closely correlated with the prognosis of melanoma. The gene discussed is YTHDF2; the disease is melanoma.