Beyond threshold alarms, the TPE program and the fact that our T1D patients were mainly on CSII, and considering the high variability of the benefits between patients, another explanation for the improvement of metrics over 6 months might be the patients baseline characteristics (age, duration of diabetes, BMI, biological HbA1c, and insulin sensitivity evaluated by eGDR).16,17 Among all those characteristics, only the score of insulin sensitivity showed a linear association with the change in TAR and TIR. This evidence concerns the gene INS and type 1 diabetes mellitus.