INS and Hypoglycemia: In our study, positive and clinically relevant outcomes could be explained by the educational approach at the initiation of the DG4 device, the need for capillary blood glucose calibration every 12 h, the presence of audible alarms to warn any hypoglycemia and hyperglycemia episodes thus encouraging greater patient involvement on a daily basis, and the significant proportion of CSII users more reactive to insulin dose adjustments based on threshold alarms or glycemic trends.13,18