PARP1 and neoplasm: If the tumor is genetically deficient in BRCA2, it will not beable to perform HR and therefore cause irreparable DNA damage, leadingto cell death.23 In the second mechanism,the PARPi binds to the PARP1 enzyme on the chromatin, thus trappingit in mechanism referred to as PARP trapping; this causes a lesionthat must be repaired which, due to compromised HR, is not possibleand causes cell death.