DNA-PKcs is dysregulated in numerous cancers such asmelanoma,where it encourages angiogenesis and tumor migration, and it has beendiscovered that the DNA-PKcs is associated with the secretion of prometastaticproteins through modification of the tumor microenvironment.52 DNA-PKcs dysregulation has also been observedin hepatocellular carcinoma53 and myeloma54 and is associated with radioresistance in cancersincluding thyroid,55 oral cavity,56 and cervical cancer.57 Here, PRKDC is linked to cancer.