Synthetic lethality has reported between WEE1 and ATR inhibitors.This was achieved through the combination of the WEE1 inhibitor AZD1775(formally MK-1775) (40, Figure 13A) and two ATR inhibitors 11 and ETP-46464 (41, Figure 13B).111 In thisstudy synergistic killing of cancer cells from various tissues wasobserved, but untransformed cell remained unaffected. The gene discussed is ATR; the disease is cancer.