DNA-PKcs is dysregulated in numerous cancers such asmelanoma,where it encourages angiogenesis and tumor migration, and it has beendiscovered that the DNA-PKcs is associated with the secretion of prometastaticproteins through modification of the tumor microenvironment.52 DNA-PKcs dysregulation has also been observedin hepatocellular carcinoma53 and myeloma54 and is associated with radioresistance in cancersincluding thyroid,55 oral cavity,56 and cervical cancer.57 This evidence concerns the gene PRKDC and neoplasm.