PRKDC and neoplasm: As shown by its complementaryfunctions with ATM, DNA-PKcs playsa key role in DNA repair in HR and NHEJ; the role of DNA-PKcs in DNArepair has been reviewed comprehensively by Goodwin et al.50 In addition to these well documented DNA damagerepair pathways, DNA-PKcs is also involved with various processesthat are thought to be important for tumor progression, such as cellcycle progression, transcription, and telomere maintenance,51 making DNA-PKcs an attractive target for cancertherapy.