PRKDC and neoplasm: The most potent of this series were pyrimidoisoquinolinone(32, Figure 10) (DNA-PK IC50 = 0.28 μM) and NU7026 (33, Figure 10) (DNA-PK IC50 = 0.23 μM), which were able to sensitize tumor celllines to ionizing radiation and DNA damaging agents.94