To study if P2X7 receptor is important in maintaining the extracellular pool of CD14 during infection, we performed the cecal ligation and puncture (CLP) procedure in wild-type and P2rx7−/− mice and we found that the lack of P2X7 receptor expression resulted in reduced levels of cell-free CD14 in both serum and peritoneal lavage (Figure 3b). Here, P2RX7 is linked to infection.