P2RX7 and Sepsis: In order to elucidate if extracellular CD14 released by P2X7 has a role during sepsis, we next analyzed bacterial dissemination, as it is known that extracellular CD14 contributes to the clearance of invading bacteria and that the P2X7 receptor is important for controlling bacterial content during sepsis (Csóka et al., 2015; Lévêque et al., 2017).