Therefore, P2X7 receptor-dependent release of CD14 seems to have a role in bacterial infection restraint, and while we studied CD14 release from macrophages, there are also reports indicating that non-hematopoietic cells such as epithelial or endothelial cells that also express the P2X7 receptor could release CD14, thus also influencing innate immune functions during infection (Jersmann, 2005) and in turn restoring homeostatic conditions after sepsis (Zanoni and Granucci, 2013). Here, CD14 is linked to bacterial infectious disease.