P2RX7 and Sepsis: This strongly suggests that the release of CD14 induced by P2X7 receptor during sepsis reduces the induction of cytokine by bacterial LPS, being in line with the fact that a reduced amount of CD14 at the plasma membrane impairs LPS and other PAMPs signaling (Akashi-Takamura and Miyake, 2008; Baumann et al., 2010; Weber et al., 2012) and circulating CD14 binds LPS and impair its signaling from plasma membrane receptors (Kitchens and Thompson, 2005).