To test if the deficiency in extracellular CD14 in P2rx7−/− mice during sepsis would be detrimental for survival, we treated P2rx7−/− mice with recombinant CD14 before CLP and found that mice survival was significantly increased (Figure 6b), as well as weight loss was preserved (Figure 6—figure supplement 1a). The gene discussed is CD14; the disease is Sepsis.