P2RX7 and Sepsis: We and others have found that P2rx7−/− mice present higher mortality during sepsis (Csóka et al., 2015; Martínez-García et al., 2019), and here we also confirm that treating wild-type mice with the pharmacological P2X7 receptor-antagonist A438079 before CLP also increases the likelihood of mortality (Figure 6a).